Better Curcumin

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We added boron to provide even more benefits. There is no other formula like this. Scroll down to see the benefits.

 

 

Curcumin is a good antioxidant, but it is especially effective in helping to reduce inflammation. For these reasons, curcumin provides many health benefits. The raw material used in the Better Curcumin formula is the only form of curcumin shown to pass through the blood brain barrier and improve memory (Cox KH, et al. 2015).

This study also showed a significant reduction in both total cholesterol and LDL cholesterol, the so-called bad cholesterol.

The following research show that this form of curcumin is 65 times more bioavailable than regular curcumin (Gota VS, et al. 2010).

 

Curcumin

 

Curcumin has an anti-inflammatory effect. It protects the human chondrocytes (cartilage cells) from degradation (breakdown) affecting several biochemical pathways (Henrotin Y, et al. 2010). It is also a good antioxidant.

Curcumin has been found to reduce IL-1beta induced NF-kappaB activation (Buhrmann C, et al. 2011). These are inflammatory compounds.

Curcumin also down regulated MMP-1, 9 and 13, enzymes involved in tendon degradation.

 

 

More health benefits of Curcumin

 

Vascular endothelial function declines with aging and is associated with an increased risk of cardiovascular disease.

Curcumin has been documented to improve flow-mediated dilation as much as exercise (Akazava N, et al. 2012).

Flow-mediated dilation is an indicator of endothelial function. Consequently, the health and function of the blood vessels improved, because the endothelium is the inner lining of the blood vessels.

Inflammation plays an important role in the pathogenesis of atherosclerosis and cardiovascular disease.

C-reactive protein, an inflammatory marker, has been identified as a strong predictor and independent risk factor of cardiovascular disease, and supplementation with curcumin has been associated with a significant reduction in C-reactive protein (Sahebkar A, 2014).

Higher levels of the inflammatory marker hs-CRP (highly sensitive C-reactive protein) have been associated with worse performance in executive function (Wersching H, et al. 2010). High levels of hs-CRP can be used to identify individuals at an increased risk for cognitive decline (Komulainen P, et al. 2007).

Based on another study, working memory and mood were found to be significantly better after taking curcumin for 4 weeks (Cox KH, et al. 2015).

Total cholesterol and LDL cholesterol were also significantly reduced.

 

Using Curcumin Extracts

 

Taking 500 mg of a patented curcumin extract twice daily for 8 weeks was associated with a decrease in depressive symptoms (Lopresti AL, et.al., 2014). This needs to be linked to the correct reference and has to be exchanged in the reference list for the Lopresti 2015.

Research has shown a significant effect of curcumin in lowering the inflammatory marker IL-6 (Derosa G, et al. 2016). 

IL-6 is one of the inflammatory markers involved in a symptomatic disc of the low back (Kim J.H., et al. 2008).

Curcumin has been found to reduce IL-1beta induced NF-kappaB activation (Buhrmann C, et al. 2011). These are inflammatory compounds involved in tendonitis. 

Elevated inflammatory markers have also been found to increase the risk of fractures in both men and women (Cauley JA, et al. 2016Cauley JA, et al. 2007). 

 

 

Boron provides several health benefits. (Pizzorno L, 2015).

 

 

Reduced inflammation is one of these benefits.

 

The researchers of this double-blind study gave boron to patients diagnosed with knee osteoarthritis and found that the boron reduced the inflammatory markers C-reactive protein and erythrocyte sedimentation rate when compared with the placebo group (Scorei R, et.al., 2011).

After 60 days of supplementation with boron in patients with rheumatoid arthritis, the inflammatory markers erythrocyte sedimentation rate, highly sensitive C-reactive protein, IL-1alpha, IL-6 and TNF-alpha were all significantly reduced, and symptoms were improved (Hussain SA, et.al., 2016).

 

Bones

Boron supplementation markedly reduced the urinary excretion of calcium and magnesium in postmenopausal women, consistent with the prevention of calcium loss and bone demineralization (Neilsen FH, et.al., 1987). 

 

 

References:

 

Antony B(1), Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin. Indian J Pharm Sci. 2008 Jul-Aug;70(4):445-9. doi: 10.4103/0250-474X.44591.

Akazawa N1, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012 Oct;32(10):795-9. doi: 10.1016/j.nutres.2012.09.002. Epub 2012 Oct 15.

Buhrmann C(1), Mobasheri A, Busch F, Aldinger C, Stahlmann R, Montaseri A, Shakibaei M. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2011 Aug 12;286(32):28556-66. doi: 10.1074/jbc.M111.256180. Epub 2011 Jun 13.

Cauley JA1, Barbour KE2, Harrison SL3, Cloonan YK1, Danielson ME1, Ensrud KE4,5,6, Fink HA5,6,7, Orwoll ES8, Boudreau R1. Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS). J Bone Miner Res. 2016 Dec;31(12):2129-2138. doi: 10.1002/jbmr.2905. Epub 2016 Jul 25.

Cox KH(1), Pipingas A(1), Scholey AB(2). Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015 May;29(5):642-51. doi: 10.1177/0269881114552744. Epub 2014 Oct 2.

Derosa G1, Maffioli P2, Simental-Mendía LE3, Bo S4, Sahebkar A5. Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2016 Sep;111:394-404. doi: 10.1016/j.phrs.2016.07.004. Epub 2016 Jul 5.

Gota VS1, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 Feb 24;58(4):2095-9. doi: 10.1021/jf9024807.

Helliwell TR, Kelly SA, Walsh HP, Klenerman L, Haines J, Clark R, Roberts NB. Elemental analysis of femoral bone from patients with fractured neck of femur or osteoarthrosis. Bone. 1996 Feb;18(2):151-7.

Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, Mathy-Hartert M, Shakibaei M, Mobasheri A. Biological actions of curcumin on articular chondrocytes.Osteoarthritis Cartilage.2010 Feb;18(2):141-9.

Hussain SA, Abood SJ, Gorial FI. The adjuvant use of calcium fructoborate and borax with etanercept in patients with rheumatoid arthritis: Pilot study. J Intercult Ethnopharmacol. 2016 Dec 8;6(1):58-64. doi: 10.5455/jice.20161204021549. eCollection 2017 Jan-Mar.

Kim JH1, Studer RK, Sowa GA, Vo NV, Kang JD. Activated macrophage-like THP-1 cells modulate anulus fibrosus cell production of inflammatory mediators in response to cytokines. Spine (Phila Pa 1976). 2008 Oct 1;33(21):2253-9. doi: 10.1097/BRS.0b013e318182c35f.

Komulainen P1, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala EL, Gylling H, Nissinen A, Rauramaa R. Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age Ageing. 2007 Jul;36(4):443-8. Epub 2007 May 30.

Militaru C, Donoiu I, Craciun A, Scorei ID, Bulearca AM, Scorei RI. Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life. Nutrition. 2013 Jan;29(1):178-83. doi: 10.1016/j.nut.2012.07.006. Epub 2012 Nov 13.

Naghii MR, Mofid M, Asgari AR, Hedayati M, Daneshpour MS. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J Trace Elem Med Biol. 2011 Jan;25(1):54-8. doi: 10.1016/j.jtemb.2010.10.001. Epub 2010 Dec 3.

Nielsen FH, Hunt CD, Mullen LM, Hunt JR. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J. 1987 Nov;1(5):394-7.

Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas). 2015 Aug;14(4):35-48. Review.

Sahebkar A1. Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis. Phytother Res. 2014 May;28(5):633-42. doi: 10.1002/ptr.5045. Epub 2013 Aug 7.

Scorei R, Mitrut P, Petrisor I, Scorei I. A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis.  Biol Trace Elem Res. 2011 Dec;144(1-3):253-63. doi: 10.1007/s12011-011-9083-0. Epub 2011 May 24.

Wersching H1, Duning T, Lohmann H, Mohammadi S, Stehling C, Fobker M, Conty M, Minnerup J, Ringelstein EB, Berger K, Deppe M, Knecht S. Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology. 2010 Mar 30;74(13):1022-9. doi: 10.1212/WNL.0b013e3181d7b45b.